How Polynucleotides Can Rejuvenate Your Skin: The Science Behind the Latest Breakthrough in Aesthetic Medicine

In the ever-evolving landscape of aesthetic medicine, polynucleotides have emerged as a revolutionary treatment option for those seeking natural, long-lasting skin rejuvenation. These powerful biological molecules are transforming how we approach anti-aging treatments, offering a scientifically-backed solution that works at the cellular level to restore youthful skin quality.

What Are Polynucleotides?

Polynucleotides are long chains of nucleotides—the fundamental building blocks of DNA and RNA. In aesthetic medicine, these molecules are typically derived from highly purified salmon or trout DNA, which closely resembles human DNA. Through advanced purification processes, these natural compounds are made safe and biocompatible for human use, with virtually no risk of allergic reactions.

Unlike traditional dermal fillers that simply add volume, polynucleotides act as bio-stimulators, working at the cellular level to trigger your skin's own regenerative processes.

The Science: How Polynucleotides Work

When injected into the skin, polynucleotides function as powerful signaling molecules that activate fibroblasts—the cells responsible for producing collagen, elastin, and other essential components of healthy skin. This activation triggers a cascade of regenerative processes:

1. Enhanced Collagen Production: Clinical studies have shown polynucleotides can increase collagen production by up to 47% within just 23 days.

2. Improved Skin Thickness: Research demonstrates a 52% improvement in epidermal thickness within the same timeframe.

3. Cellular Regeneration: Polynucleotides stimulate the repair and regeneration of skin cells, promoting overall tissue health.

4. Anti-inflammatory Effects: These molecules possess natural anti-inflammatory properties, helping to calm irritated skin and reduce redness.

   
   

Key Benefits of Polynucleotide Treatment

The clinical evidence supporting polynucleotides is compelling. Multiple studies have documented significant improvements in various aspects of skin health:

Enhanced Hydration and Elasticity

A clinical trial involving 143 patients demonstrated marked improvement in skin elasticity and hydration, with high levels of both patient and physician satisfaction. Another study found that after 20 weeks of treatment, skin hydration improved by an impressive 115%, while elasticity increased by 38%.

Reduction in Fine Lines and Wrinkles

Research has shown that 91% of patients experienced clinical improvement in the reduction of superficial fine lines and wrinkles. The treatment is particularly effective for delicate areas like the periorbital region (around the eyes), where 90% of patients saw a reduction in fine, superficial wrinkles.

Improved Skin Quality and Texture

In a study focusing on facial middle third rejuvenation, participants experienced a 51.1% improvement in skin brightness and a 39.6% improvement in skin elasticity. The treatment also showed significant benefits for addressing acne scars, with severity scores decreasing from 7.6 to 4.2 on average.

Long-lasting Results

Unlike some aesthetic treatments that require frequent touch-ups, the effects of polynucleotides are sustained. Studies have shown that improvements in skin texture and quality can last up to six months post-treatment, with many practitioners reporting results lasting 6-9 months.

The Treatment Process

Polynucleotide treatment is minimally invasive and typically involves:

• Initial Course: Usually 2-3 treatment sessions spaced 3-4 weeks apart

• Procedure Time: 30-45 minutes per session

• Minimal Downtime: Patients can return to normal activities immediately

• Natural Results: Improvements develop gradually over 2-3 months as collagen production increases

Safety Profile

With over 1.8 million uses and no reported adverse or allergic reactions, polynucleotides have demonstrated an exceptional safety profile. The intensive purification process ensures the treatment is well-tolerated by most patients, including those with sensitive skin.

Who Can Benefit?

Polynucleotides are suitable for individuals experiencing:

• Fine lines and wrinkles

• Loss of skin elasticity

• Dehydrated or dull skin

• Uneven skin texture

• Early signs of aging

• Acne scarring

The treatment is particularly effective for those seeking a natural approach to skin rejuvenation without the immediate volume changes associated with traditional fillers.

Conclusion

Polynucleotides represent a paradigm shift in aesthetic medicine, offering a scientifically-proven approach to skin rejuvenation that works with your body's natural processes. By stimulating cellular regeneration and collagen production at the deepest levels, this treatment provides comprehensive improvements in skin quality that go beyond surface-level fixes.

As the clinical evidence continues to mount, polynucleotides are establishing themselves as a cornerstone treatment for those seeking natural, long-lasting skin rejuvenation. Whether you're looking to address early signs of aging or enhance your overall skin quality, polynucleotides offer a safe, effective solution backed by robust scientific research.

References

1. Cavallini M, et al. Consensus report on the use of PN-HPT™ (polynucleotides highly purified technology) in aesthetic medicine. J Cosmet Dermatol. 2021;20(3):615-623. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984045/

2. Araco A, Araco F. PN-HPT® (Polynucleotides Highly Purified Technology) in facial middle third rejuvenation. Exploring the potential. J Cosmet Dermatol. 2022;21(2):615-624. Available at: https://pubmed.ncbi.nlm.nih.gov/34791770/

3. Lee YJ, Kim HT, Jin Lee You. Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial. J Dermatolog Treat. 2022;33(1):254-260. Available at: https://www.aestheticnursing.co.uk/content/clinical/a-literature-review-on-polynucleotide-efficacy-on-skin-rejuvenation-and-review-of-the-regulatory-status-and-guidelines-around-polynucleotides/

4. Palmieri IP, et al. Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness. PMC. 2024. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11311621/

5. Khan A. Introducing polynucleotides. Journal of Aesthetic Nursing. 2022;11(10). Available at: https://www.aestheticnursing.co.uk/content/comment/introducing-polynucleotides/